I'm not gonna step on Tracy's toes here, but increasing the Spark plug Gap and adding the MPG remedy to Gas have had pretty impressive results on my truck, Pre-groove.
Also, look into swapping out your o2 sensors if you never have before. I did that too, and I'm in the 25MPG range...smaller truck, smaller engine, a bit more mileage, but already up from ~21 MPG
I've also RVS'd my engine, gearbox and differential...it all adds up, Gene.
Other than these things, all you have to consider is an Air-Oil seperator on your PCV re-route, addressing your vehicle's grounding situation (it helps the sensors function accurately to report to the computer for it to make adjustments - look for Alternatorman on youtube for the big 4 grounding). You may be able to bypass the EGR system too (which is a massive, factory-implemented vacuum leak as far as I'm concerned). And then, there's the Throttle plate shaping to consider...Have you cleaned your MAF sensors? Checked your tire pressures are at maximum? These are the easy things. I've discovered that a port/polish of my intake and exhaust might help my engine breathe better, and there are roller rockers I can add that I've heard add HP and torque. And an Underdrive crank pulley and electric cooling fan, and a lower temp thermostat, all for similar results of more HP and torque. I'm not interested in HP, but Torque to get me moving, and a lighter touch on the gas to keep me moving while eating less fuel and polluting less are ALL of interest. The question is, how FAR am I willing to go, and where do the gains become less impressive/justifiable? You have to look into that and ask the same questions yourself.
Another thing I've done to my truck - and you may or may not be able to do a similar one on yours - was to take the "cooling" lines off my intake manifold ("Hot water bypass"). I'm not familiar with your Dodge's engine. Poke around on the forums for tips/hints- this Hemi isn't uncommon.