you mean do a re-learn? I wouldn't. I'd just drive it.
If you start getting codes related to the sensors you've treated, you should go back to a re-learn. If that keeps returning the same code, you have to look at what you've done to the sensor signal and reverse engineer what's happening to fix it.
When I first put my EFIE on, I was getting over 60mpg just puttering around town, but on the highway things got funny. I had already and long since treated my MAP with a modification circuit to great effect and wanted the EFIE to take it a step further. Unfortunately, both together at their "optimal settings" made the car do funny things on the highway - not safe things. So I had to back both of them off then re-tweak them in unison and I'm back to very close to that 60mpg in town, along with having eliminated the safety issues I had created. I've said it before, but it gets to a point where you have to step back and look at the whole and find small optimizations every step along the way rather than throwing a heavy hammer at it to make a BIG IMMEDIATE difference. Streamline a bit here, tweak a bit there...it really is #allthesmallthings in concert:
Small groove. small increase in spark gap and make sure your ignition wires have the smallest resistance possible. small voltage adjustments at specific sensors. small changes in maintenance (clean the MAP and MAF sensors at each oil change, where air filter gets replaced as well). small change to the PCV system. small tubes of friction reduction oil modifier/surface restorative in the right places.
The devil really IS in the details...if you mind the pennies, the pounds really do take care of themselves.